The standard mortality ratio (SMR) for patients with acromegaly with elevated IGF-1 (above the patient’s upper limit of normal) levels is higher than that of the general population (SMR = 2.5, 95% confidence interval [CI] 1.6–4.0), as is the SMR for patients with acromegaly with GH > 2.5 μg/L (SMR = 1.9, 95% CI 1.5–2.4) [4]. The gene discussed is IGF1; the disease is acromegaly.