From the limited number of studies that have assessed this relationship, data suggest that elevated IGF-1 and/or GH levels at diagnosis may be associated with arthropathy [13], heart disease [11, 15], malignant neoplasms [15], diabetes mellitus [11, 12, 14, 15], hypertension [11, 12], and sleep apnea [11]. This evidence concerns the gene GH1 and diabetes mellitus.