Evidence suggests that Bifidobacteria supplementation, which serves to restore a balanced microbial composition, modulates immune function, gut microbiota and intestinal mucosal adhesion in IBS patients [8], with studies demonstrating positive effects on epithelial cell adherence, reinforcement of tight junctions, stimulation of IgA production and cell-mediated immunity, which are impaired in IBS patients [9, 10]. The gene discussed is CD79A; the disease is irritable bowel syndrome.