Beyond a significantly delayed onset of symptomatic AML disease (median survival 26 days vs. 18 days with p < 0.0001 for ppp-RNA treated (n = 16) versus untreated mice (n = 16)), ppp-RNA treatment led to long-term remission in 3 out of 16 (19%) of the treated animals, demonstrating the potential of systemic RIG-I activation in the therapy of AML. Here, RIGI is linked to acute myeloid leukemia.