In addition they suggest that, reminiscent of the effects seen in the C1489 mouse model, ppp-RNA might sensitize human AML cells to T cell-mediated cell death (via enhanced MHC-class I/TCR recognition and Fas/Fas-ligand interaction) and to checkpoint blockade of the PD-1/PD-L1 axis. The gene discussed is FAS; the disease is acute myeloid leukemia.