Considering the prominent role of IFN signaling involved in ppp-RNA treatment of C1498-GFP AML (Fig. 3b), we analyzed PD-L1 expression on tumor cells infiltrating lung tissue of C57BL/6 mice, as in this organ we observed the strongest effects of ppp-RNA on tumor load (see Fig. 1b). This evidence concerns the gene IFNA1 and acute myeloid leukemia.