CD68 and neoplasm: In addition, bioinformatic analysis based on TCGA database (http://cancergenome.nih.gov) indicated a significant positive correlation between the mRNA expression levels of H1HR and CD68 (r = 0.314, P = 0.026) (Supplementary Fig. S1B), implying that also myeloid cells present in the tumor microenvironment express H1HR and may contribute to the observed negative impact of H1HR expression on prognosis.