Similar binding was observed with broadly neutralizing monoclonal antibodies which bind to influenza HA, suggesting that this type of binding is not unique to intestinal IgA.10 These observations prompted the authors to suggest that the majority of species might be coated by SIgA that arises from T cell-independent responses, does not require somatic mutations and binds in germline configuration.10 However, nonconventional binding has not been formally excluded. This evidence concerns the gene CD79A and influenza.