In our Cox proportional hazards regression model, we have calculated many AML-associated mutant genes and found that DNMT3A and FLT3 are high risk factors for CN-AML patients (HR > 1, P < 0.05), while NPM1 and NRAS are favorable genes (HR < 1, P < 0.05), and the PDE7B gene is the most significant one (unfavorable gene) by comparing the P value. The gene discussed is NPM1; the disease is acute myeloid leukemia.