The OS time of 396 AML patients (P < 0.0001, Log-rank test, Supplementary Fig. 3A left) and 203 CN-AML patients (P < 0.0001, Log-rank test, Supplementary Fig. 3A right) with high level PDE7B was significantly lower than that of low level PDE7B. The gene discussed is PDE7B; the disease is acute myeloid leukemia.