MYC and cancer: C-MYC was initially identified as a cell homologue of a retroviral oncogene,19,20 and it is activated in 50% of human cancers;21 further, it can promote the proliferation of cancer cells by regulating 10–15% of the genes in the human genome.22 Reports show that c-MYC is overexpressed in many human cancers and can also regulate cell cycle and cell metabolic processes.23 Abnormal expression of c-MYC will lead to tumorigenesis.