We measured the expression of six different Zn-binding proteins in tissue microarrays (TMAs) from OPSCC patients by IHC in matched tumor and normal tissue, including: Lipocalin-1 (n = 63), AZGP1 (n = 68), albumin (n = 26), S100A7 (n = 53), S100A7 (n = 53), S100A8 (n = 51) and S100A9 (n = 50). This evidence concerns the gene S100A8 and neoplasm.