In the discovery cohort, low cytoplasmic DARPP-32 expression was significantly associated with ER and PgR positive tumours (χ2 = 25.893, d.f. = 1, P < 0.001 and χ2 = 7.384, d.f. = 1, P = 0.007 respectively) and absence of triple negative disease (χ2 = 10.607, d.f. = 1, P = 0.001) (Table 1). Here, PGR is linked to neoplasm.