Importantly, western blot analysis also confirmed the on-target effect of OTSSP167 as evidenced by clear reduction in MELK protein levels in the GCB-DLCBL cell line SU-DHL-6, the ABC-DLBCL cell line U2932 and the MCL cell line Jeko-1 and in Aurora B kinase protein levels in U2932 and Jeko-1 cells (Fig. 2e). Here, MELK is linked to diffuse large B-cell lymphoma.