According to GWAS database GRASP21, CHRM3 is an epilepsy risk gene and CHRM3 SNP rs10925980 was nominally associated with genetic generalized epilepsies (P = 1.90 × 10−6) and Ca-HL (P = 0.03) in EAs (see Supplementary Table S4). Here, CHRM3 is linked to idiopathic generalized epilepsy.