A role for reticulon proteins in the autophagic process has been previously suggested; in particular it has been demonstrated that in mouse neuroblastoma RTN-3 inhibits autophagy via the enhanced interaction between Bcl-2 and Beclin 1, which favors Bcl-2-mediated inhibition of Beclin 1-dependent autophagy7. Here, BCL2 is linked to neuroblastoma.