HIC-5 expressed in CAFs contributes to the invasion and migration of breast cancer and prostate cancer through ECM remodeling and cytokine secretion, and it is responsible for colorectal cancer tumorigenesis.25–28 Despite the studies above, the mechanism of how CAF-derived HIC-5 modulates tumor progression remains unclear. The gene discussed is TGFB1I1; the disease is Familial prostate cancer.