CEP290 and Leber congenital amaurosis: In ophthalmology, the use of a 2’OMe-modified AON on a PS backbone to cover the cryptic spice site created from c.2991 + 1655A > G of CEP290 mutation in fibroblasts from LCA patients, thus redirecting the splicing process, was shown to be effective and caused a three to 4.5-fold upregulation of wild-type mRNA in LCA patient-derived fibroblasts equaling that in wild-type cells [82].