PANX1 and age-related macular degeneration: As pannexin-1 physically interacts with the P2X7R, is functionally linked to the P2X7R and can be activated by various mechanisms [38,40,41,42,43,44,45], investigating the interaction between the P2X7R and pannexin-1 channel in the RPE and other retinal cells would be critical to understand the role of P2X7R/pannexin-1 pathways in the RPE and AMD.