KDM1A and Anxiety: Concurrent inhibition of Lsd1 by siRNA in the CeA was sufficient to prevent miR-137 antagomir-mediated rescue of the anxiety-like behaviors seen in the EPM in AIE adult rats (Fig. 3B), as one-way ANOVA revealed a group level effect for percentage of open arm entries (F(4,27) = 32.8, p < 0.001), time spent in the open arms (F(4,27) = 15.7, p < 0.001), and number of closed arm entries (F(4,27) = 3.77, p = 0.015).