Regarding the significance of S100A10 expression in human colorectal cancer cells, Sayo Suzuki et al. reported that the upregulation of S100A10 showed significantly increased IC50 of L-OHP in COLO-320 CRC cells and downregulation of S100A10 in HT29 cells showed no apparent effect on sensitivity to L-OHP [7, 9]. Here, S100A10 is linked to colorectal carcinoma.