LZTR1 and chronic myelogenous leukemia, BCR-ABL1 positive: For instance, in a drug resistant model of chronic myeloid leukemia, cullin-based ubiquitin ligase 3 (CUL3)/leucine zipper-like transcription regulator 1 (LZTR1) complex inhibition leads to increased MAPK signaling and reduced sensitivity to chemotherapy [85].