In contrast, IRE1 significantly attenuates the expression of proteins related to EMT and invasiveness of glioma, including thrombospondin-1, secreted protein acidic and rich in cysteine (SPARC) and decorin, while IRE1 is positively associated with pro-angiogenic factors such as VEGF-A, IL-1β, IL-6, and IL-8 in malignant glioma [157,158], suggesting that a comprehensive analysis of IRE1 arm of the UPR is pivotal for the adequate elucidation of its role in modulating angiogenesis and invasiveness. Here, ERN1 is linked to central nervous system cancer.