In contrast, IRE1 significantly attenuates the expression of proteins related to EMT and invasiveness of glioma, including thrombospondin-1, secreted protein acidic and rich in cysteine (SPARC) and decorin, while IRE1 is positively associated with pro-angiogenic factors such as VEGF-A, IL-1β, IL-6, and IL-8 in malignant glioma [157,158], suggesting that a comprehensive analysis of IRE1 arm of the UPR is pivotal for the adequate elucidation of its role in modulating angiogenesis and invasiveness. This evidence concerns the gene ERN1 and glioma.