Glioblastoma tumorigenesis has been investigated also in chimeric models exploiting CRISPR-cas9 technology combined with ESC-derived cerebral organoids [110] Particularly, glioblastoma within neural organoids can be generated by simultaneously disrupting TP53 tumor suppressor and expressing oncogenic HRasG12V in a small number of cells. Here, TP53 is linked to glioblastoma.