Concerning histone demethylases, Jumonji C domain KDMs members of family GASC1/KDM4C and JMJD1C/KDM3C demethylating agents of repressive histone marker H3K9 and KDM7B/PHF8 which specifically demethylate H3K27me1/2, play a critical role in ESCC cancer development [54,55,56]. The gene discussed is KDM4C; the disease is esophageal squamous cell carcinoma.