Moreover, the KDM4 subfamily, particularly KDM4C/JMJD2C, which target methylated H3K9 and H3K36 histone marks, contributes to cancer initiation and development, and is associated with hypoxic status in breast cancer [74,75], whereas, in renal cell carcinoma cell lines, KDM3A, KDM4B and KDM5B were shown to be regulated by HIF family. The gene discussed is KDM4C; the disease is cancer.