TFF2 and digestive system neoplasm: Two major types of metaplastic lineages have been identified adjacent to cancers of the stomach: an intestinal-type metaplasia with the characteristic presence of goblet cells [53] and a spasmolytic polypeptide-expressing metaplasia (SPEM) which expresses trefoil factor 2 (TFF2), then designated as spasmolytic polypeptide [54].