Supporting this hypothesis, treatment with the iNOS inhibitor aminoguanidine reduced the tumor load in mice carrying a mutant Cdx2 allele (Apc+/Δ14; Cdx2+/−), while having no effect on mice with only wild-type Cdx2 alleles (Apc+/Δ14; Cdx2+/+) [35]. This evidence concerns the gene APC and neoplasm.