Comparative cross-species genomics evaluations of BC progression from pre-invasive DCIS to IDC detected 16 markers with attendant genomic changes, i.e., UBE2C, CCNB2, CEP55, TOP2A, BIRC5, TPX2, SHCBP1, KIAA0101, PTTG1, UBE2T, DEPDC1, NUSAP1, CCNB1, HELLS, KIF4A, and RRM2 that may be included in BC invasion and progression in young women [51]. Here, TOP2A is linked to breast cancer.