Pdgf-c Tg mice treated at 9 weeks of age (liver fibrosis) and 32 weeks (HCC) with locked nucleic acid anti-miR-214 showed a marked reduction in fibrosis and tumor incidence and these effects were attributed to repression of EGFR and TGF-β signaling pathways [82]. This evidence concerns the gene PDGFC and Hepatic fibrosis.