In the Cox proportional hazard models, patients in T1 had an increased risk of ESRD after adjusting for age, sex, DM, systolic blood pressure, eGFR, proteinuria, overhydration, and IL-6 (HR: 3.15, 95% CI: 1.95–5.07, p < 0.001) (Table 3). The gene discussed is IL6; the disease is diabetes mellitus.