Although this study obviously analyzed only those neoplasms requiring surgery (that is not usually the choice of treatment for these tumors) and included only a small proportion of OPGs, it highlights the following important issues: first, the heterogeneity of the molecular landscape of NF1-associated gliomas; second, the presence of lymphocytic infiltrates in a fraction of these tumors, thus indicating a potential application of immunotherapy. The gene discussed is NF1; the disease is central nervous system cancer.