A guinea pig model of ZIKV infection presents an attractive alternative to the above models due to the physiologic similarities between humans and guinea pigs, which include reproductive physiology and estrous cycle, and homology between immune systems (major histocompatibility molecules (MHC), complement systems, IFNγ pathways, IL-8/12 receptors, and CD8 sequences) [51]. The gene discussed is CXCL8; the disease is Zika virus infectious disease.