Of note, the augmented C1s staining in RDEB tumor cells could correlate with the activation of phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways, and contribute to the elevated migratory and metastatic abilities of cancerous cells in RDEB patients [89]. The gene discussed is C1S; the disease is recessive dystrophic epidermolysis bullosa.