CCR5 and cancer: Cancer cells secrete RANTES or induce fibroblasts to secrete RANTES which interacts in a paracrine or autocrine manner on CCR5-positive tumor cells to sustain their proliferation, to recruit immunosuppressive cells (T-reg cells, monocyte), to trigger osteoclasts activation and bone metastasis, to sustain neoangiogenesis, and to support the dissemination of tumor cells.