TLR2 and chronic obstructive pulmonary disease: The Bacteroides Prevotella, one of the most abundant genera in the healthy lung microbiome, appears to exhibit a TLR2-dependent low inflammatory potential, whereas the Proteobacteria Haemophilus influenzae and Moraxella catarrhalis, linked with lung microbiome alterations in asthma and COPD, induce severe TLR2 independent (and probably TLR4-dependent) lung inflammation and injury in mice [57].