ACHE and memory impairment: Also, it is well known that impaired function of AChE, an enzyme that catalyzes the breakdown of acetylcholine, is accompanied by memory impairment [70], since AChE has a significant part in cholinergic neurotransmission [71], and low levels of AChE usually result in abnormal elevated levels of the neurotransmitter acetylcholine in the cholinergic synapses, which lead to excessive motivation and stimulation of muscarinic and nicotinic receptors [72].