HSPG2 and Seizure: Supported by the behavioral and morphological outcomes as well as electroencephalographic waves observed in previous preclinical studies, the PLC-induced seizure model has been proposed as an animal model with similarity in characteristics to TLE, and numerous previous studies showed that acute systemic administration of a high dose of the muscarinic cholinergic agonist PLC (400 mg/kg) provoked behavioral alternations and convulsions in all tested animals which developed within 30 min to SE [8,9,11,48,49,50].