HRH3 and Bilateral tonic-clonic seizure: In a recent study, the novel histamine H3R antagonist E177, which belongs to the non-imidazole histamine H3 receptor (H3R) antagonists class, was found to provide full in vivo protection against seizures in three different seizure models in rodents, including maximal electroshock- and pentylenetetrazole-induced generalized tonic-clonic seizure, following acute systemic administration (2.5, 5, 10, and 15 mg/kg, i.p.)[28].