In that context, neutrophils are able to release S100A8/A9, which are considered as DAMPs and found in large amounts in biological samples from patients with metabolic inflammatory diseases (e.g., gout) and autoimmune diseases (e.g., rheumatoid arthritis, RA) [26,27,28,29]. This evidence concerns the gene IGKV1D-22 and rheumatoid arthritis.