Novel and clinically trialed thiosemicarbazones with potent and marked anti-tumour activity in vitro and in vivo have been successfully used to increase NDRG1 expression (Chen et al., 2012, Kovacevic et al., 2013, Le and Richardson, 2004, Whitnall et al., 2006, Yuan et al., 2004). Here, NDRG1 is linked to neoplasm.