Because Fcγ Receptor I Alpha (FcgRI, CD64) has been shown to directly recognize Escherichia coli by murine macrophages in the context of meningeal infection [22] and to mediate bacterial invasion, we further assessed whether this receptor would mediate the internalization of B. burgdorferi in the absence of opsonins (antibodies). The gene discussed is FCGR1A; the disease is infectious meningitis.