BICD2 and Atrophy: The role of Bicaudal homologous 2 Drosophila gene (BICD2) associated with spinal and lower extremity muscle atrophy, which was upregulated in pansteatitis and Sphingosine -1-phosphate phosphatase 2 (SGPP2) involved in Sphingosine -1- phosphate metabolism, and Doublesex–mab-related transcription factor 1 (DMRT1) responsible for sex gonad development and germ cell differentiation that were downregulated in pansteatitis may lead to muscular atrophy of the lower extremitiea dn and poor fertility.