The role of Bicaudal homologous 2 Drosophila gene (BICD2) associated with spinal and lower extremity muscle atrophy, which was upregulated in pansteatitis and Sphingosine -1-phosphate phosphatase 2 (SGPP2) involved in Sphingosine -1- phosphate metabolism, and Doublesex–mab-related transcription factor 1 (DMRT1) responsible for sex gonad development and germ cell differentiation that were downregulated in pansteatitis may lead to muscular atrophy of the lower extremitiea dn and poor fertility. The gene discussed is BICD2; the disease is muscular atrophy.