MiR-221 can also act as an oncomiR–overexpression of miR-221 was shown to be associated with cell proliferation, colony formation and invasion in prostate cancer cell lines, by targeting the expression of the tumor suppressor ARHI [42].Despite their pervasive nature in various cancer types, we showed here that the combination of hsa-miR-200c-3p and -221-3p as diagnostic markers increases the specificity and sensitivity to detect OC. Here, DIRAS3 is linked to Familial prostate cancer.