In Rag2 KO mice, which lack both conventional T/B lymphocytes, 5ASKH infection caused delayed but progressive and non-ulcerative lesion development, whereas Friedlin infection caused delayed and lesser lesion development (Fig 2A and 2B) despite a similar level of parasite burden in Friedlin- or 5ASKH-infected footpads and pLN (Figs 2C and S2). This evidence concerns the gene PLN and infection.