Finally, symbiotic bacteria from the genera Kosakonia and Chromobacterium, which are found naturally in the midgut of Anopheles gambiae and Aedes aegypti mosquitoes, produce and secrete reactive oxygen intermediates [69], histone deacetylases [70] and aminopeptidases [71] that exert direct anti-Plasmodium and anti-dengue activity. This evidence concerns the gene CPQ and dengue disease.