Expression is dysregulated in TDP-43-deficient amyotrophic lateral sclerosis (ALS). Neuronal morphology and cognition in ALS. miR-132 can delay neurite outgrowth in vitro and impair radial neuronal migration in embryonic mouse neocortex in vivo. Involved in synaptic plasticity. Process of neovascularization. Recent reports have highlighted vascular defects in both skeletal muscle and spinal cord of SMA patients. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.