Deletion of the miRNA biogenesis enzyme Dicer in MNs either using Olig2-Cre or ChAT-Cre results in MN degeneration that mimics certain hallmarks of SMA and ALS (Chen and Wichterle, 2012; Haramati et al., 2010; Tung et al., 2019). The gene discussed is OLIG2; the disease is amyotrophic lateral sclerosis.