Interestingly, in addition to the role of SMN in RNA processing, recent studies have uncovered unexpected interactions of SMN with miRNA biogenesis proteins including fragile X mental retardation protein (FMRP), KH‐type splicing regulatory protein (KSRP) and fused in sarcoma/translocated in liposarcoma (FUS/TLS) (Piazzon et al., 2008; Sun et al., 2015; Tadesse et al., 2008; Yamazaki et al., 2012) (Figure 4). This evidence concerns the gene SMN1 and sarcoma.