BMP2 and glioblastoma: This led to the demethylation of histone H3K4, in turn inhibiting the transcription of the BMP‐2 gene and promoting glioblastoma tumorigenesis.41, 42 In a study of osteoblastic differentiation, KDM1A deficiency enhanced BMP‐2 signalling in human mesenchymal stem cells and mice and promoted an osteoblastic phenotype.43