Previously, there have studies to explore the association of MTHFR rs4846049 polymorphism and susceptibility to migraine [20], ischemic stroke [21], preeclampsia [22, 23], colorectal cancer [18], coronary artery disease [24, 25], attention-deficit/hyperactivity disorder [26], and cerebral palsy [27]. The gene discussed is MTHFR; the disease is migraine disorder.