Additionally, the axis Let7/HMGA2 seems to be important not only for the initiation of GC but also for its recurrence, since Takahashi and colleagues demonstrated that the remaining gastric mucosal areas following surgical resection, which are highly related to GC recurrence, display a significant reduction in Let7a expression concomitantly with an increase in the EMT transcription factor Snail [55]. The gene discussed is HMGA2; the disease is gastric cancer.