HMGA1 and colorectal carcinoma: In this sense, it was demonstrated that HMGA1 overexpression was able to induce the emergence of polyps in a transgenic mouse model [68], thus reinforcing the relationship between HMGA1 expression deregulation and the early steps of CRC carcinogenesis, since polyps represent a precancerous lesion that, when surgically resected, prevents CRC development [68].