HMGA1 and adenoma: In this study, the authors observed that HMGA1 expression progressively increases from adenoma with mild atypia to adenoma with severe atypia, and, finally, to CRC, thus showing that the alterations in the HMGA1 expression pattern comprise an initial event along malignant evolution, thus indicating a strong potential of HMGA1 expression levels to be used in CRC early detection [4].