EGFR and non-small cell lung carcinoma: In France, a multicenter study named ERMETIC (Evaluation of EGFR Mutation Status for the administration of EGFR-TKIs in Non-Small Cell Lung Carcinoma) was conducted to validate numerous methods based on restriction enzyme analysis, allele-specific amplification, single-base extensions, fluorogenic allele-specific oligonucleotide hybridization probe, pyro-sequencing, or high-resolution melting (33).