In previous studies, the role of AGEs-RAGE interaction in both diabetic nephropathy and nondiabetic renal diseases has been extensively studied and it is well accepted that AGE-RAGE signaling pathway is crucial for renal or glomerular inflammation, a hallmark of chronic kidney diseases (Abel et al., 1995; Tanji et al., 2000; Wendt et al., 2003; Che et al., 2011). This evidence concerns the gene RENBP and diabetic kidney disease.