NLRP3 and diabetes mellitus: Suppression of AGEs-RAGE pathway protected the kidney from pro-inflammatory injury, in particular, in renal glomeruli during DM (Wendt et al., 2003; Chow et al., 2006; Che et al., 2011) and antagonists of RAGE inhibited AGEs-induced NLRP3 inflammasome activation and consequent chronic renal injury (Yeh et al., 2017).