Although there is no direct evidence in literature showing the role of AGEs in mediating D-ribose-induced activation of the NLRP3 inflammasome in the kidney, some previous studies did confirm that D-ribose increased the level of AGEs in cultured human kidney 293 cells, human neuroblastoma SH-SY5Y cells, and primary cultured hippocampal neurons (Wei et al., 2009). The gene discussed is NLRP3; the disease is neuroblastoma.