Moreover, the phosphatase and tensin homology gene (PTEN), which had been suggested to participate in the occurrence of cardiac fibrosis after MI (Tao et al., 2017; Zhang and Cui, 2018), was determined as a target of miR-144-3p, and the biological functions of miR-144-3p-mediated-PTEN were further characterized on proliferation, migration, and ECM synthesis of cardiac fibroblast cells. This evidence concerns the gene PTEN and myocardial infarction.