Previous studies have recommended that PTEN suppresses the activation of PI3K-Akt signaling pathway (Maehama, 2006; Bassi and Mak, 2016) which has been suggested to accelerate MI (Liu S. et al., 2019) and regulated myocardial infarct size and fibrosis (Wang et al., 2019). The gene discussed is PTEN; the disease is myocardial infarction.