AKT1 and myocardial infarction: Previous studies have recommended that PTEN suppresses the activation of PI3K-Akt signaling pathway (Maehama, 2006; Bassi and Mak, 2016) which has been suggested to accelerate MI (Liu S. et al., 2019) and regulated myocardial infarct size and fibrosis (Wang et al., 2019).