CRP and cardiovascular disorder: In order to verify the performance of the fabricated LSPR sensor chip, C-reactive protein (CRP), which is a biomarker for cardiovascular disease and inflammation (Lagrand Wim et al., 1999; Albrecht et al., 2008; Pultar et al., 2009; Bryan et al., 2013), was selected as a model sample and the detection characteristics of the plasmonic substrate were evaluated.