In this context, sertraline (SERT), a selective serotonin reuptake inhibitor (SSRI), presents several therapeutic uses, ranging from management of depression, to control of obsessive–compulsive disorder and social phobia, to treatment of chronic pain (Kreilgaard et al., 2008; Santuzzi et al., 2012). Here, SLC6A4 is linked to major depressive disorder.