First, the SPINT2 promoter is frequently methylated, resulting in downregulation of the SPINT2 gene by epigenetic silencing (45–48); and second, SPINT2 inhibited the motility and invasion of cancer cells as well as their viability and anchorage independent growth (46–49), in part by inhibiting the activation of HGF as alluded to above. The gene discussed is SPINT2; the disease is cancer.