While a strong association with a short survival was also observed for AML, lung adenocarcinoma and Ewing sarcoma, the opposite was true for instance for kidney carcinoma, meningioma, metastatic melanoma and OC (Figure 6C), suggesting that SPINT2 may not be classified as a general tumor suppressor or promoter. This evidence concerns the gene SPINT2 and lung adenocarcinoma.