While a strong association with a short survival was also observed for AML, lung adenocarcinoma and Ewing sarcoma, the opposite was true for instance for kidney carcinoma, meningioma, metastatic melanoma and OC (Figure 6C), suggesting that SPINT2 may not be classified as a general tumor suppressor or promoter. The gene discussed is SPINT2; the disease is metastatic melanoma.