Nevertheless, tumor cells inhibit the activation of NK cells triggered by lacking of MCH class I expression through the release of soluble molecules such as MHC class I chain-related protein A (MICA) and MHC class I chain-related protein B (MICB), which bind to the activator receptor (NKG2D) on NK cells surface causing the endocytosis and its subsequent degradation, leading to the inactivation of NK cells (136). Here, MICA is linked to neoplasm.