TNF and neoplasm: After the recognition of non-own peptides (such as tumor antigens) through MHC-I, CD8 T cells will be activated causing cytokine release, mainly TNF-α and IFN-γ (147), as well as their cytoplasmic granule (perforin and granzime B) content toward neoplastic cells, it also induces apoptosis through the interaction of dead molecules such as Fas with Fas Ligand present in the tumor cells, causing lysis and apoptosis of the tumor cells (148).