In addition, lactate produced by the tumor cell promotes the overexpression of IL-23, present in different types of tumors (colon, breast, stomach, melanoma) (156), the presence of this cytokine promotes expression of IL-17, Matrix metalloprotease 9 (MMP-9), increases angiogenesis and reduces the infiltration of CD8 in the tumor, promoting immunosuppression and tumor growth (157). Here, CD8A is linked to melanoma.