MICB and neoplasm: Nevertheless, tumor cells inhibit the activation of NK cells triggered by lacking of MCH class I expression through the release of soluble molecules such as MHC class I chain-related protein A (MICA) and MHC class I chain-related protein B (MICB), which bind to the activator receptor (NKG2D) on NK cells surface causing the endocytosis and its subsequent degradation, leading to the inactivation of NK cells (136).