For instance, in a lung cancer model, CAFs underwent increased aerobic glycolysis and promoted the epithelial mesenchymal transition, migration and invasion of non-small-cell lung carcinoma (NSCLC) cells, in contrast, NSCLC cells experienced enhanced oxidative phosphorylation upon CAF stimulation, with an increase in ATP generation, thereby an activation of the PIK3/Akt and MAPK/ERK pathways occurred (123). This evidence concerns the gene AKT1 and non-small cell lung carcinoma.