The tyrosine kinases involved in the Y10 phosphorylation of LDHA are HER2, the avian sarcoma viral oncogene v-src homolog (Src) and the Fibroblast growth factor receptor 1 (FGFR1), this phosphorylation promotes the Warburg effect and pro-invasive and pro-metastatic potential of cancer cells (73, 74). The gene discussed is FGFR1; the disease is cancer.