MAP1LC3A and colorectal cancer: Furthermore, colorectal cancer cells induce oxidative stress in microenvironment fibroblast, which then undergo metabolic changes, including increased expression of glycolytic enzymes, reduced TCA cycle enzymes and autophagy proteins such as microtubule-associated protein 1A/1B-light chain 3 (LC3), Bcl-2 interacting protein 3(BNIP3), and p62 (124).