ERBB2 and breast cancer: Among these trials, we have the BOLERO-1 and BOLERO-3, both evaluating the role of everolimus, an mTOR inhibitor, in combination with trastuzumab plus paclitaxel as first-line treatment (BOLERO-1) (63) or in combination with trastuzumab and vinorelbine in trastuzumab-resistant advanced HER2-positive BC (BOLERO 3) (123).