ERBB2 and breast cancer: After this revision, we would like to conclude that the HER2-E subtype should be established itself as the best predictor of prognosis and clinical outcomes of the BC with this intrinsic subtype, what would allow for the extension of the use of anti-HER2 drugs for HER2-negative tumors and to improve the selection of patients with HER2+ BC for combination of anti-HER2 therapies.